Understanding the metabolic bases of embryogenesis is an important challenge in developmental biology. The neural crest (NC) is a vertebrate-specific structure composed of multipotent cells transiently present in the dorsolateral region of the neural tube. After migrating into the embryo, these cells help in the formation of many organs. Researchers at the Institute for Advanced Biosciences(IAB) in Grenoble led by Chantal Thibert and Marc Billaud have now shown that the tumor suppressor Lkb1 is an essential regulator of the metabolic pathways required for the differentiation of several NC derivatives. The work is published in Science Advances.
Read the research paper: LKB1 specifies neural crest cell fates through pyruvate-alanine cycling. A.G. Radu, S. Torch, F. Fauvelle, K. Pernet-Gallay, A. Lucas, R. Blervaque, V. Delmas, U. Schlattner, L. Lafanechère, P. Hainaut,N. Tricaud, V. Pingault,N. Bondurand, N. Bardeesy, L. Larue, C. Thibert and M. Billaud. Science Advances 10.1126/sciadv.aau5106