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The interferon effect in high-risk pregnancy

By 12th July 2019 July 14th, 2019 No Comments

Researchers from the Institut Pasteur, the CNRS, Inserm, Necker-Enfants Malades Hospital (AP-HP) and Université de Paris have discovered a new cellular mechanism involved in abnormal placental development during some high-risk pregnancies. The mechanism alters placental development, which can serious complications, and is linked with the production of interferon, a molecule produced in response to infection, especially viral infection. The research is reported in Science.


Fluorescence microscopy of fused cells (in green) and nucleus (in blue). Credit: © Fabrice Hyber — Organoïde-Institut Pasteur © Institut Pasteur

Read the research paper: IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise. Julian Buchrieser et alScience 10.1126/science.aaw7733.

Read the news release from Inserm.