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The Barhl2 protein “locks” cell identity during embryogenesis

By 13th June 2019 June 16th, 2019 No Comments

The so-called “canonical” Wnt signalling pathway plays a decisive role in embryogenesis, stem cell biology and carcinogenesis. It is important to know how Wnt factors regulate genetic information to better understand embryonic development and abnormalities in this development. New work, published in the journal Development, has revealed a hitherto unseen Wnt pathway inhibitory mechanism that irreversibly and transmissibly blocks cell differentiation.

Barhl2

Image provided by: Béatrice Durand

The researchers involved in this study are from the Institut Curie (CNRS/Institut Curie/Inserm/Univ Paris Sud) and are led by Béatrice Durand.

Read the research paperBarhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formationSena E, Rocques N, Borday C, Muhamad Amin HS, Parain K, Sitbon D, Chesneau A, Durand BC., Development 10.1242/dev.173112.