The so-called “canonical” Wnt signalling pathway plays a decisive role in embryogenesis, stem cell biology and carcinogenesis. It is important to know how Wnt factors regulate genetic information to better understand embryonic development and abnormalities in this development. New work, published in the journal Development, has revealed a hitherto unseen Wnt pathway inhibitory mechanism that irreversibly and transmissibly blocks cell differentiation.
Read the research paper: Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation. Sena E, Rocques N, Borday C, Muhamad Amin HS, Parain K, Sitbon D, Chesneau A, Durand BC., Development 10.1242/dev.173112.