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The ASB2α protein regulates the immune response in colorectal cancer

By 8th June 2019 June 12th, 2019 No Comments

A better understanding of the mechanisms controlling T cell function is a major challenge for manipulating the immune response for therapeutic purposes. Researchers at the Institute of Pharmacology and Structural Biology led by Isabelle Lamsoul have now found that effector T lymphocytes play an important role in establishing and regulating the immune response during tumour formation. This new result, published in the journal Cancer Immunology Research, highlights a new regulator of the anti-tumour immune response in colorectal cancer.

Reference: The E3 ubiquitin ligase Asb2α in T helper 2 cells negatively regulates anti-tumor immunity in colorectal cancerSpinner CA, Lamsoul I, Métais A, Febrissy C, Moog-Lutz C and Lutz PG, Cancer Immunology Research .

Read the article from the Institute of Pharmacology and Structural Biology (IPSB).