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Taking temperature at the nanoscale, brain abnormalities in Huntington’s disease detectable early on, link between ancient retroviruses and psychosis

By 17 juillet 2020 juillet 19th, 2020 No Comments

Extracts from « LabNews »

Chemical thermometers take temperature at the nanoscale

Researchers from the Coordination Chemistry Laboratory and the Laboratory for Analysis and Architecture of Systems, both of the CNRS, have developed molecular films that can measure the operating temperature of electronic components on the nanometre scale. These patented temperature-sensitive molecules are extremely stable, even after being used millions of times, and could soon be deployed in the microelectronics industry. The researchers, including Azzedine Bousseksou, Gábor Molnár and Karl Ridier, report their work in Nature Communications.

Temperature map of a gold nanowire on a silicon substrate, Joule-heated by the application of an electrical current of 7 mA, obtained through infrared thermography (top) and a spin-crossover surface thermometer (bottom). While heating remains undetectable in infrared due to low thermal and spatial resolution, temperature distribution is well resolved using an SCO-based thermometer, which reveals a “hot spot” resulting from a malfunction of the component. © Ridier et al.

Brain abnormalities in Huntington’s disease are detectable in the embryonic stage

Researchers and clinicians from Inserm, Grenoble Alpes University, Sorbonne University, CNRS and AP-HP, the Grenoble Institute of Neurosciences and the Paris Brain Institute, have discovered cerebral anomalies in the brains of human embryos carrying the mutation responsible for Huntington’s, a genetic neurological disease. This work, reported in Science, questions the mechanisms of silent disease progression and when and how to treat patients in the future, say the researchers, including Sandrine Humbert, and Alexandra Durr.

IllustrationCP_Inserm_maladie Huntington

© Monia Barnat/Grenoble Institut des neurosciences/Inserm, Université Grenoble Alpes

A link between ancient retroviruses and psychoses

A translational study on humans and animals, published in Science Advances, has established a clear link between the presence in the blood of the envelope protein of endogenous human retroviruses, the disruption of synaptic communication and the manifestation of psychotic symptoms. The work is a result of collaboration between member teams from the Fondation FondaMental of the Institut Interdisciplinaire des Neurosciences de Bordeaux, the University of Bordeaux, the CNRS, the Université Paris Est Créteil, Inserm, the Université Grenoble Alpes, GeNeuro and the Université de Lyon.