Like all viruses, the human immunodeficiency virus, or HIV, parasitizes the cell it infects so that it can multiply and release new viruses. To do this, the virus needs to divert the proteins from the cell it infects to its own benefit because it does not have all the components necessary spread itself. The proteins of the human cell can thus somehow be crucial allies for the virus. Identifying these proteins is therefore important for understanding the replication cycle of the virus and potentially inhibit it. In a new study published in Nature Microbiology, researchers at the Institut de recherche en infectiologie de Montpellier (IRIM) – (CNRS / Université de Montpellier) describe how they discovered that the human protein Transportin or TRN-1 allows the virus to replicate effectively.
Read the research paper: Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJ. Nat. Microbiol.