To treat diseases better, we must understand how they arise. Researchers in Germany, France and the UK have now succeeded in using high-resolution imaging to show how the HI virus spreads between living cells and which molecules it requires for this purpose. Using superresolution STED fluorescence microscopy, they provide direct proof for the first time that the AIDS pathogen creates a certain lipid environment for replication. “We have thus created a method for investigating how this multiplication can potentially be prevented,” says team leader Christian Eggeling of the Friedrich Schiller University Jena. The results are reported in Science Advances.
Read the research paper: HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly. C. Favard, J. Chojnacki, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling, D. Muriaux. Science Advances 10.1126/sciadv.aaw8651