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Researchers identify the toxin responsible for Legionella growth

By 27 juillet 2019 juillet 6th, 2020 No Comments

The toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. This is the new finding from researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, led by Sagar Bhogaraju, and Goethe University, Frankfurt, led by Ivan Dikic. SidJ hijacks human protein Calmodulin and uses it to its own advantage in one of the classic examples of pathogenic bacteria exploiting the human molecular machinery and turning it against us. This makes SidJ an ideal target to curb Legionella infection. The results are reported in Nature.

Read the research paper: Sagar Bhogaraju, Florian Bonn, Rukmini Mukherjee, et al. Inhibition of SidE ubiquitin ligases through SidJ/Calmodulin catalyzed glutamylation. Nature.

Read the news alert from the EMBL.