In plants, interference by RNA (or RNAi) is one of the major defence mechanisms against viruses. At the heart of this machinery, the Argonaute1 protein (AGO1) is the target of certain viral proteins called RNAi suppressors (VSR) such as the Turnip Yellow Virus P0 protein. Researchers at the Institut de biologie moléculaire des plantes (IBMP) – (CNRS/Université de Strasbourg) have now deciphered the association of PO and AGO1 with endoplasmic reticulum and the mechanism that leads to the specific degradation of AGO1 in the vacuole. The study is published in PNAS.
Read the research paper: The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1. Michaeli S, Clavel M, Lechner E, Viotti C, Wu J, Dubois M, Hacquard T, Derrien B, Izquierdo E, Lecorbeiller M, Bouteiller N, De Cilia J, Ziegler-Graff V, Vaucheret H, Galili G, Genschik P. PNAS