lab snippets

Measuring brain activity in milliseconds and ultrasound for neurological disorders

By 18 avril 2019 juillet 6th, 2020 No Comments

Researchers from King’s College London, Harvard and INSERM-Paris say they have discovered a new way to measure brain function in milliseconds using magnetic resonance elastography (MRE). This could help with diagnosing and understanding neurological diseases like Alzheimer’s, dementia, multiple sclerosis, or epilepsy.

For more information: press release from King’s College London.

Meanwhile, researchers from the Physics for Medicine Laboratory Paris (Inserm, ESPCI Paris, PSL University, CNRS) together with teams of the University of Oxford and the Institute of the Brain and the Spinal Cord (Inserm, CNRS), are now proposing a non-invasive solution (applied through the skull bone) based on ultrasound waves to modulate neural activity. Such treatment can be used in case in which therapeutic drugs fail or are inefficient, but existing techniques are invasive and inaccurate, They have published their findings in a series of three articles, published in eLife, Neuron and Nature Neurosciences.

References:

Verhagen L, Gallea C, Folloni D, Constans C, Jensen DEA, Ahnine H, Roumazeilles L, Santin M, Ahmed B, Lehericy S, Klein-Flügge MC, Krug K, Mars RB, Rushworth MFS, Pouget P, Aubry JF, Sallet J. Offline impact of transcranial focused ultrasound on cortical activation in primates. Elife (2019) 8:e40541.

Folloni D, Verhagen L, Mars RB, Fouragnan E, Constans C, Aubry JF, Rushworth MFS, Sallet J. Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation. Neuron (2019)

Fouragnan E, Chau BKH, Folloni D, Kolling N, Verhagen L, Klein-Függe M, Tankelevitch L, Papageorgiou GK, Aubry JF, Sallet J, Rushworth MFS. The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change. Nature Neuroscience (2019)

For more information: press release from ESPCI Paris.