Hematopoietic stem cells (HSCs) are responsible for constantly replenishing blood cells throughout life. One of the major challenges in regenerative medicine is to produce tailor-made HSCs to replace defective ones in patients suffering from blood related diseases. This would overcome the shortage of donor HSCs available for the clinic. To produce bona fide HSCs in vitro, researchers need to better understand where, when and how HSCs are physiologically produced in vivo.
Researchers in Catherine Robin’s group at the Hubrecht Institute and Thierry Jaffredo’s group at UPMC, LBD IBPS in Paris have now discovered a hitherto unappreciated hematopoietic wave that occurs in the bone marrow of late foetuses and young adults that produces HSCs from resident haemogenic endothelial cells of somite origin. This transient haematopoietic wave lies in between the end of embryonic blood production and the beginning of adult bone marrow hematopoietic production in both chicken and mice. The research is published in Nature Cell Biology.
Read the research paper: Laurent Yvernogeau, Rodolphe Gautier, Laurence Petit, Hanane Khoury, Frédéric Relaix, Vanessa Ribes, Helen Sang, Pierre Charbord, Michèle Souyri, Catherine Robin, Thierry Jaffredo. In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium. Nature Cell Biology
Read the press release from the Hubrecht Institute