Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble led by Marco Marcia have discovered that the tumour suppressor MEG3 adopts a complex 3D structure to carry out its function. They were also able to fine-tune its activity by targeted manipulation of this architecture. The results of this study, published in Molecular Cell, might help to advance diagnosis and treatment of certain types of cancers.
Read the research paper: Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway. Tina Uroda et al. Molecular Cell