IgG antibodies and neutrophils may contribute to the severity of most cases of anaphylactic shock (a potentially fatal allergic reaction sometimes caused by the use of drugs during surgery) via an additive effect. This new result from researchers at the Institut Pasteur, Inserm, the Paris Public Hospital Network (AP-HP), the CNRS, Paris-Sud University and Sorbonne University will help improve diagnosis and treatment for patients with this type of shock. The work is published in Science Translational Medicine.
Read the research paper: An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis. Friederike Jönsson et al. Science Translational Medicine.