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Excess calorie intake early in life leads to colitis later on

By 10th November 2019 November 28th, 2019 No Comments

Thanks to epidemiological studies, researchers now know that obesity and inflammatory bowel disease (IBD) are linked. Animal models also show that a maternal high-fat diet and maternal obesity make offspring more likely to be obese. A team at the Institut Pasteur and Inserm is now reporting that excess calorie intake by neonatal mice born to mothers on a high fat diet or made to force feed have more permeable intestines during weaning. These mice also express pro-inflammatory cytokines and microbiota that produce hydrogen sulphide.

These intestinal changes lead to an increased susceptibility to colitis in adults and long-term susceptibility to IBD.

The research is reported in Nature Metabolism.

Read the research paper: Excess calorie intake early in life increases susceptibility to colitis in adulthood. Ziad Al Nabhani et al. Nature Metabolism