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DNA tweezers study the interaction between a drug and its target at the molecular scale

By 30th September 2019 No Comments

The efficacy of a drug strongly depends on the time that the drug molecule spends near its target, which is usually a protein. If this interaction time is long, the drug will have a stronger effect than if the interaction time is short. Researchers at the Institut de Biologie de l’Ecole normale supérieure (IBENS) – (CNRS, INSERM, ENS Paris) led by Terence Strick and Charlie Gosse have now developed a new very-high resolution technique for observing the interaction of a single drug molecule with a single target molecule in real time. The work, reported in Nature Nanotechnology, opens up new perspectives in drug development, therapeutic antibodies and materials science.

Read the research paper: A modular DNA scaffold to study protein-protein interactions at single-molecule resolution. Kostrz D, Wayment-Steele HK, Wang JL, Pande VS, Strick TR & Gosse C. Nature Nanotechnology 10.1038/s41565-019-0542-7

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