Anatomical analysis of the cerebral cortex by MRI can be used to diagnose 80% of patients with Alzheimer’s disease. But could analysis of another brain structure provide better results? Yes, say researchers from Inserm, the Université de Paris, and the CEA (French Alternative Energies and Atomic Energy Commission), led by Maxime Bertoux, who is now an Inserm researcher at the Degenerative and Vascular Cognitive Disorders unit (Inserm / Université de Lille / Lille University Hospital). According to the new study, published in Neurobiology of Aging, morphological analysis of the cortical sulci could make it possible to identify Alzheimer’s disease in 91% of cases. The size of these sulci also appears to be associated with the stage of disease progression and cognitive decline. The research points to the potential value of this method in diagnosis and patient follow-up.
Read the research paper: Sulcal morphology in Alzheimer’s disease: an effective marker of diagnosis and cognition. Maxime Bertou et al. Neurobiology of Aging