Atopic dermatitis, or eczema, primarily affects infants and children, and manifests itself in hypersensitivity to allergens in the environment. A skin disease characterized by flare-ups, it is often treated with topical anti-inflammatories. A new study led by Inserm researcher Nicolas Gaudenzio, from the Epithelial Differentiation and Rheumatoid Autoimmunity Unit (UDEAR – Inserm / UT3 Paul Sabatier), in collaboration with colleagues at Stanford University in the US shows that immune cells and sensory neurons interact in the skin to form units that can detect allergens and trigger inflammation. The discovery provides an insight into how atopic dermatitis works, and points the way to new therapeutic possibilities. Thee findings have now been published in Nature Immunology.
Read the research paper: House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation. Stephen Galli et al. Nature Immunology 10.1038/s41590-019-0493-z