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Blood stem cell immune memory could impact future vaccination strategies

By 15 mars 2020 juillet 6th, 2020 No Comments

Researchers led by Prof. Michael Sieweke, from the Center for Regenerative Therapies TU Dresden (CRTD) and the Center of  Immunology of Marseille Luminy (CNRS, INSERM, Aix-Marseille University) have discovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future. These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell.

Immune cells by fluorescence microscopy: Blood stem cells remember a previous attack and produce more immune cells like these macrophages to fight a new infection. © Sieweke lab/CIML

Source: Press release from TU Dresden

Reference: C/EBPb dependent Epigenetic Immune Memory in Hematopoietic Stem Cells. Bérengère de Laval et al. Cell Stem Cell